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Insomnia may be a risk factor for severe rupture of an aneurysm in the brain

A recent study found that insomnia may be a potential risk factor for brain hemorrhage from a ruptured aneurysm, along with more well-known risk factors such as smoking and high blood pressure.

More than 3% of adults worldwide have malformations of an unruptured cranial aneurysm, most of which will never rupture.

About 2.5 percent of intracranial aneurysms may rupture, resulting in a subarachnoid hemorrhage (SAH), also called brain hemorrhage, a type of stroke that occurs when a blood vessel on the surface of the brain ruptures and bleeds into the space between the brain and skull.

“A ruptured aneurysm is extremely lethal,” said study author Dr Susanna C. Larsson, associate professor in the Cardiovascular and Nutrition Epidemiology Unit at the Karolinska Institutet in Stockholm, and the Medical Epidemiology Unit at Uppsala University in Uppsala in Sweden. Modifiable risk factors that can help prevent rupture of an aneurysm.

The researchers sought to determine whether various factors were associated with intracranial aneurysm and/or ruptured aneurysm.

They studied established risk factors such as smoking and high blood pressure, and assessed the relationship between aneurysms and coffee consumption, sleep, physical activity, body mass index (BMI), blood glucose levels, type 2 diabetes, blood pressure, cholesterol, and inflammation. Chronic and renal function.

The team used data from several genome-wide association studies to measure genetic associations with lifestyle and cardiac risk factors

They then used genetic information from a meta-analysis by the International Consortium of Stroke Genetics to identify approximately 6,300 cases of intracranial aneurysms and approximately 4,200 cases of subarachnoid aneurysms.

Cases of intracranial aneurysms and subarachnoid hemorrhages were compared with more than 59,500 controls to determine genetic predisposition to aneurysms, and according to the analysis:

A genetic predisposition to insomnia was associated with a 24% increased risk of intracranial aneurysm, subarachnoid hemorrhage, and aneurysm.

1271702865 Image credit: MICROGEN IMAGES/SCIENCE PHOTO LIBRARY / Getty Images.

The risk of intracranial aneurysm was three times higher for smokers versus non-smokers.

The risk of developing an intracranial aneurysm was approximately three times higher for every 10 mmHg increase in diastolic blood pressure (the lowest number in a blood pressure reading).

High triglyceride levels and a high BMI have not been shown to increase the risk of intracranial aneurysm and subarachnoid hemorrhage.

“The relationship between insomnia and intracranial aneurysms has not been previously reported, and these findings require confirmation in future studies,” Larson said. “Our research supports the thinking that risk factors that people can change or manage may influence cerebral aneurysm and bleeding risk.” Confirmation, and future research should examine ways to integrate this knowledge into prevention and treatment programs.”

According to a 2016 American Heart Association scientific statement, sleep duration and quality influence lifestyle behaviors and cardiovascular health, sleep disturbances and insufficient and poor sleep are associated with an increased risk of developing high blood pressure.

The study summary notes that treating people with sleep disturbances may provide clinical benefits, particularly for blood pressure.

The limitations of the study included the lack of sufficient information to adequately analyze some of the risk factors. In addition, the analysis included only people of European descent. Therefore, the results may not be generalizable to people of diverse racial and ethnic groups.

Source: Medical Express

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